Introduction The focus of this technology is the ability of yeast reversibly to open up the junctions between cells to aid drug delivery. By micro-encapsulating active ingredients inside the yeast cells, this technology enhances paracellular movement of active ingredients in mucus-rich areas such as buccal, oral, nasal, vaginal, anal and others. Application could be by means of powder, tablet, capsule, chewable tablet, chewing gum, melting film strip, spray, cream or gel. Yeast offers a very cost attractive alternative to chitosan as permeation enhancer, and mucoadhesive mechanism.
This technology offers specific opportunities to companies seeking non-invasive drug delivery solutions, such as non-invasive insulin delivery. It may also be possible to have a multi-drug system where a water-soluble active ingredient, formulated together with yeast cells, also has a lipophilic/water insoluble active ingredient entrapped within those yeast cells.
The core technology is supported by other patent areas specifically using yeast as carriers or microcapsules particularly in topical antifungal applications. Taste-masking is also possible if yeast is used as a carrier for flavour delivery.
Micro-encapsulation as drug delivery platform. The technology offers new modalities for
Oral mucosal drug delivery (analgesics, hormones, insulin).
Targeted delivery of a lipophilic active anywhere from the mouth to the lower bowel.
Topical delivery.
Taste-masking of volatile lipophilic flavours.
Better uptake in creams, gels, and ointments.
Improved nasal spray drug delivery.
Non-invasive insulin delivery.
A new way to package and deliver off-patent drugs.
This technology is supported by 1 US patent and 5 European patents.

Company Sinew Consulting Group

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